Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP3 | P08254 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14270776 | 0.90 | TP53 (0.60) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL4927605 | 0.89 | HDAC3 (0.59) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL4925354 | 0.88 | HDAC3 (0.69) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL4927460 | 0.87 | HDAC3 (0.67) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL4927113 | 0.87 | HDAC3 (0.64) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL14270792 | 0.87 | HDAC3 (0.61) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL4929525 | 0.86 | RAB9A (0.57) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL4929544 | 0.86 | HDAC3 (0.58) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL25002620 | 0.85 | HDAC2 (0.62) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 | |
| SCHEMBL14270767 | 0.85 | HDAC3 (0.65) | TP53ALDH1A1HPGDSMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | claimed |
| EP-1838690-A2 | COMPOUNDS WITH KV4 ION CHANNEL ACTIVITY | Devgen N.V. (BE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006066879-A2 | COMPOUNDS WITH KV4 ION CHANNEL ACTIVITY | DEVGEN N.V. (BE) | 2006-06-29 | — | — | WO | claimed |
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | DEVGEN NV (BE) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039442-A1 | Compounds With Kv4 Ion Channel Activity | KCNA4, HCN4, KCNN4 | TP53 4191/4885ALDH1A1 2549/4885HPGD 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.