⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781231 | 0.77 | IRAK4 (0.34) | — | |
| SCHEMBL1766616 | 0.75 | EPHX1 (0.31) | — | |
| SCHEMBL115508 | 0.75 | — | — | |
| SCHEMBL21386086 | 0.74 | ADH1B (0.32) | — | |
| SCHEMBL18502882 | 0.74 | ADH1B (0.32) | — | |
| SCHEMBL4917512 | 0.72 | ADH1A (0.58) | — | |
| SCHEMBL18236726 | 0.71 | MDM2 (0.35) | — | |
| SCHEMBL4924932 | 0.71 | DPP4 (0.33) | — | |
| SCHEMBL20079170 | 0.71 | MDM2 (0.35) | — | |
| SCHEMBL20678853 | 0.71 | DPP4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319019-A1 | Therapeutic Agents | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| EP-1833802-A2 | 1,2-DIPHENYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS CB1 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006067428-A2 | 1, 2-DIPHENYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS CB1 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |