Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413200 | 1.00 | PARP1 (0.42) | PARP1NUDT1METAP2METAP1HSP90AA1 | |
| SCHEMBL29371690 | 0.88 | CA12 (0.48) | HSP90AA1IDO1CDK2CA12CA1 | |
| SCHEMBL10417 | 0.88 | CA12 (0.48) | HSP90AA1IDO1CDK2CA12CA1 | |
| SCHEMBL28015378 | 0.88 | CA12 (0.48) | HSP90AA1IDO1CDK2CA12CA1 | |
| SCHEMBL29570997 | 0.86 | CA12 (0.47) | HSP90AA1IDO1CDK2CA12CA1 | |
| Benzene SCHEMBL29025391 | 0.86 | CA12 (0.47) | HSP90AA1IDO1CDK2CA12CA1 | |
| Phosphine SCHEMBL29179322 | 0.86 | CA12 (0.47) | HSP90AA1IDO1CDK2CA12CA1 | |
| Bromide SCHEMBL5616601 | 0.86 | CA12 (0.47) | HSP90AA1IDO1CDK2CA12CA1 | |
| SCHEMBL21358065 | 0.86 | CA12 (0.47) | HSP90AA1IDO1CDK2CA12CA1 | |
| Hydrochloric Acid SCHEMBL10501322 | 0.86 | CA12 (0.47) | HSP90AA1IDO1CDK2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11672786-B2 | Methods of treating diseases associated with repeat instability | THE HOSPITAL FOR SICK CHILDREN | 2023-06-13 | — | — | US | claimed |
| US-20210283114-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH REPEAT INSTABILITY | OSAKA UNIVERSITY (JP) | 2021-09-16 | — | — | US | claimed |
| EP-3496713-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH REPEAT INSTABILITY | The Hospital for Sick Children (CA) | 2019-06-19 | — | — | EP | claimed |
| WO-2018029660-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH REPEAT INSTABILITY | THE HOSPITAL FOR SICK CHILDREN (CA) | 2018-02-15 | — | — | WO | claimed |
| US-8105780-B2 | Resonator sensor having capture molecule immobilised on surface (probe or mismatch binding molecule) | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-01-31 | — | — | US | claimed |
| US-20070037841-A1 | Inhibitors | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-02-15 | — | — | US | claimed |
| EP-1604993-A1 | INHIBITORS | Japan Science and Technology Agency (JP) | 2005-12-14 | — | — | EP | claimed |
| US-20050164236-A1 | Device and method of detecting mutations and polymorphisms in DNA | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2005-07-28 | — | — | US | claimed |
| EP-3496713-B1 | NAPHTHYRIDINE AZAQUINOLONE TO TREAT DISEASES ASSOCIATED WITH DNA REPEAT INSTABILITY | HOSPITAL FOR SICK CHILDREN (CA) | 2024-03-13 | — | — | EP | disclosed |
| US-11672786-B2 | Methods of treating diseases associated with repeat instability | THE HOSPITAL FOR SICK CHILDREN | 2023-06-13 | — | — | US | disclosed |
| US-20210283114-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH REPEAT INSTABILITY | OSAKA UNIVERSITY (JP) | 2021-09-16 | — | — | US | disclosed |
| EP-3496713-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH REPEAT INSTABILITY | The Hospital for Sick Children (CA) | 2019-06-19 | — | — | EP | disclosed |
| WO-2018029660-A1 | METHODS OF TREATING DISEASES ASSOCIATED WITH REPEAT INSTABILITY | THE HOSPITAL FOR SICK CHILDREN (CA) | 2018-02-15 | — | — | WO | disclosed |
| US-8105780-B2 | Resonator sensor having capture molecule immobilised on surface (probe or mismatch binding molecule) | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-01-31 | — | — | US | disclosed |
| US-20070037841-A1 | Inhibitors | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-02-15 | — | — | US | disclosed |
| US-20070037841-A1 | Inhibitors | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-02-15 | — | — | US | disclosed |
| EP-1604993-A1 | INHIBITORS | Japan Science and Technology Agency (JP) | 2005-12-14 | — | — | EP | disclosed |
| EP-1604993-A1 | INHIBITORS | Japan Science and Technology Agency (JP) | 2005-12-14 | — | — | EP | disclosed |
| US-20050164236-A1 | Device and method of detecting mutations and polymorphisms in DNA | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037841-A1 | Inhibitors | REV1, RRBP1, NQO2 | PARP1 1209/4885NUDT1 1137/4885METAP2 3006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.