Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731572 | 0.82 | SCD (0.65) | SMN1; SMN2NPC1RAB9ATP53TRPV1 | |
| SCHEMBL14082998 | 0.81 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9ATP53PTPN1 | |
| SCHEMBL12136747 | 0.77 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9ATP53PTPN1 | |
| SCHEMBL14083022 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ATP53PTPN1 | |
| SCHEMBL14082994 | 0.75 | NPC1 (0.62) | SMN1; SMN2NPC1RAB9AHDAC6TRPV1 | |
| SCHEMBL23657790 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ATP53HDAC6 | |
| SCHEMBL14082986 | 0.74 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9ATP53PTPN1 | |
| SCHEMBL14083029 | 0.74 | NPC1 (0.65) | SMN1; SMN2NPC1RAB9ATP53PTPN1 | |
| SCHEMBL14082993 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ATP53PTPN1 | |
| SCHEMBL14083028 | 0.74 | RAB9A (0.61) | SMN1; SMN2NPC1RAB9ATP53PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039629-A1 | Benzothniazole compositions and their use as ubiquition ligation inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039629-A1 | Benzothniazole compositions and their use as ubiquition ligation inhibitors | UBQLN1, NEDD4, UCHL5 | SMN1; SMN2 4114/4885NPC1 3462/4885RAB9A 3771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.