SCHEMBL4918477

SCHEMBL4918477

COc1cc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc(OC)c1OC

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.83
AKR1B1 P15121 2/20 0.83
MAPK8 P45983 1/20 0.83
CYP1B1 Q16678 6/20 0.75
MAPT P10636 6/20 0.75
CYP1A1 P04798 5/20 0.75
ALDH1A1 P00352 5/20 0.75
CYP1A2 P05177 4/20 0.75
MEN1 O00255 4/20 0.75
KMT2A Q03164 4/20 0.75
ABCC1 P33527 3/20 0.75
POLB P06746 3/20 0.75
IP6K2 Q9UHH9 3/20 0.71
XDH P47989 2/20 0.71
IPMK Q8NFU5 2/20 0.71
HDAC6 Q9UBN7 2/20 0.71
KDM1A O60341 1/20 0.71
ABCB1 P08183 4/20 0.71
CYP3A4 P08684 4/20 0.67
KDM4E B2RXH2 4/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29574485 0.95 MAOA (0.79) MAOAAKR1B1MAPK8CYP1B1MAPT
SCHEMBL6095495 0.93 MAOA (0.76) MAOAAKR1B1MAPK8CYP1B1MAPT
Corymbosin SCHEMBL29426420 0.92 ABCB1 (0.78) MAOAAKR1B1MAPK8CYP1B1MAPT
Corymbosin SCHEMBL1976826 0.92 ABCB1 (0.78) MAOAAKR1B1MAPK8CYP1B1MAPT
SCHEMBL16894650 0.91 ABCB1 (0.76) MAOAAKR1B1MAPK8CYP1B1MAPT
Tricin SCHEMBL44475 0.91 MAOA (1.00) MAOAAKR1B1MAPK8CYP1B1MAPT
Tricin SCHEMBL29712335 0.91 MAOA (1.00) MAOAAKR1B1MAPK8CYP1B1MAPT
Tricin SCHEMBL10809395 0.90 MAOA (0.97) MAOAAKR1B1MAPK8CYP1B1MAPT
SCHEMBL12378833 0.90 MAOA (0.92) MAOAAKR1B1MAPK8CYP1B1MAPT
SCHEMBL29576775 0.90 MAOA (0.92) MAOAAKR1B1MAPK8CYP1B1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118091005-A Method for detecting multiple components in deer astragalus kidney-tonifying particles 上海市第七人民医院(上海中医药大学附属第七人民医院) 2024-05-28 CN claimed
CN-114272335-A Traditional Chinese medicine formula for regulating and controlling intestinal function of children 华子昂 2022-04-05 CN claimed
EP-1067913-B1 COMPOSITIONS AND METHODS OF ADJUSTING STEROID HORMONE METABOLISM THROUGH FACILITATED ABSORPTION OF HYDROPHOBIC DIETARY COMPOUNDS BIORESPONSE LLC (US) 2012-08-29 EP claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
US-20250263774-A1 DISCOVERING NEW XENOBIOTIC SUBSTRATES OF AN UDP-GLYCOSYLTRANSFERASE WITH A HIGH-THROUGHPUT METHOD UNIV NORTH TEXAS (US) 2025-08-21 US disclosed
CN-119592609-A Gene for regulating and controlling wheat multi-stress resistance and application thereof 华中农业大学 2025-03-11 CN disclosed
CN-117740961-A Compound analysis method of liquorice and liquorice probiotics fermentation preparation 北京中医药大学 2024-03-22 CN disclosed
CN-114272335-A Traditional Chinese medicine formula for regulating and controlling intestinal function of children 华子昂 2022-04-05 CN disclosed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP disclosed
CN-105194389-A Preparation for treating bone tuberculosis and preparation method thereof ZHANG SHIHAI 2015-12-30 CN disclosed
US-20140135433-A1 TIRE WITH RUBBER CONTAINING FLAVONE THE GOODYEAR TIRE & RUBBER COMPANY (US) 2014-05-15 US disclosed
EP-2730431-A1 Rubber composition and tire with rubber containing flavone The Goodyear Tire & Rubber Company (US) 2014-05-14 EP disclosed
US-20080287374-A1 BREAST CANCER-RESISTANT PROTEIN INHIBITOR KABUSHIKI KAISHA YAKULT HONSHA (JP) 2008-11-20 US disclosed
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof EASTMAN CHEMICAL COMPANY 2007-11-01 US disclosed
US-20060135445-A1 Breast cancer-resistant protein inhibitor KABUSHIKI KAISHA YAKULT HONSHA (JP) 2006-06-22 US disclosed
EP-1591112-A1 BREAST CANCER-RESISTANT PROTEIN INHIBITOR Kabushiki Kaisha Yakult Honsha (JP) 2005-11-02 EP disclosed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed
US-6086915-A HEATING THE SOLUBILIZING EMULSIFIER, ADDING SOLVENT AND ONE OR MORE PHOSPHOLIPID SURFACTANTS, DISSOLVING IN THIS SOLUTION ONE OR MORE HYDROPHOBIC PHYTOCHEMICALS, ADDING ENCAPSULATORS, FORMING MICROEMULSION, SPRAY DRYING THE SOLUTION BIORESPONSE L.L.C. (US) 2000-07-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof ABCC4, NCOA4, NR4A3 MAOA 1628/4885AKR1B1 384/4885MAPK8 2161/4885
US-20060135445-A1 Breast cancer-resistant protein inhibitor ABCC1, BCR, BRCA1 MAOA 3721/4885AKR1B1 797/4885MAPK8 1001/4885
US-20080287374-A1 BREAST CANCER-RESISTANT PROTEIN INHIBITOR ABCC1, BCR, BRCA1 MAOA 3721/4885AKR1B1 797/4885MAPK8 1001/4885
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP MAOA 678/4885AKR1B1 1262/4885MAPK8 645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.