Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276159 | 0.81 | CYP3A4 (0.49) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL5505676 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1MAPTHSD17B10CYP3A4 | |
| SCHEMBL3060568 | 0.77 | PDPK1 (0.47) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL1806582 | 0.74 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL3047058 | 0.73 | CYP3A4 (0.51) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL4913178 | 0.72 | PIK3CA (0.46) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL21089512 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL3286995 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL3285659 | 0.71 | KMT2A (0.46) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL14860945 | 0.70 | ASH1L (0.62) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293785-A1 | SUBSTITUTED BENZOTHIAZOLE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-27 | — | — | US | disclosed |
| WO-2007121154-A2 | SUBSTITUTED BENZOTHIAZOLE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293785-A1 | SUBSTITUTED BENZOTHIAZOLE KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K2 | SMN1; SMN2 3063/4885ALDH1A1 3676/4885MAPT 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.