Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.59 |
| ▸ | DPP8 | Q6V1X1 | 13/20 | 0.59 |
| ▸ | DPP9 | Q86TI2 | 13/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 12/20 | 0.59 |
| ▸ | FAP | Q12884 | 9/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725996 | 0.91 | DPP4 (0.64) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL4725994 | 0.91 | DPP4 (0.64) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL8213072 | 0.79 | DPP4 (0.46) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL8210445 | 0.79 | DPP4 (0.47) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL4727350 | 0.79 | DPP4 (0.47) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL4728888 | 0.78 | DPP4 (0.61) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL4728883 | 0.78 | DPP4 (0.61) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL8211298 | 0.78 | DPP4 (0.61) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL8215211 | 0.78 | DPP4 (0.46) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL4726747 | 0.77 | DPP4 (0.60) | DPP4DPP8DPP9DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029217-A2 | DIPEPTIDYL PEPTIDASE IV INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2008-03-13 | — | — | WO | claimed |