SCHEMBL4920459

SCHEMBL4920459

Cn1cc(C(=O)Nc2ccccc2-c2cc(Cl)cc(Cl)c2)c(C(F)(F)Cl)n1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.51
POLB P06746 1/20 0.51
SSTR2 P30874 2/20 0.44
CHRM3 P20309 6/20 0.44
ATM Q13315 1/20 0.42
NTRK1 P04629 4/20 0.42
TDP1 Q9NUW8 1/20 0.41
JAK2 O60674 2/20 0.40
JAK1 P23458 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4918010 0.94 LMNA (0.51) LMNAPOLBSSTR2CHRM3ATM
SCHEMBL302840 0.93 LMNA (0.60) LMNAPOLBSSTR2CHRM3ATM
SCHEMBL1086049 0.89 NTRK1 (0.45) LMNAPOLBCHRM3ATMNTRK1
SCHEMBL4913373 0.88 CHRM3 (0.49) LMNAPOLBCHRM3ATMNTRK1
SCHEMBL4918647 0.88 NTRK1 (0.47) LMNAPOLBCHRM3ATMNTRK1
SCHEMBL4914980 0.88 LMNA (0.47) LMNAPOLBCHRM3ATMNTRK1
SCHEMBL4450835 0.87 LMNA (0.56) LMNAPOLBSSTR2CHRM3ATM
SCHEMBL4443888 0.86 LMNA (0.52) LMNAPOLBCHRM3ATMNTRK1
SCHEMBL3540042 0.85 NTRK1 (0.53) LMNAPOLBCHRM3ATMNTRK1
SCHEMBL4913313 0.85 SSTR2 (0.48) LMNAPOLBSSTR2CHRM3ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi BASF AKITENGESELLSCHAFT (DE) 2008-06-26 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi CBR3, C1S, PYM1 LMNA 1073/4885POLB 2358/4885SSTR2 2379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.