SCHEMBL4450835

SCHEMBL4450835

Cn1cc(C(=O)Nc2ccccc2-c2cc(F)cc(Cl)c2)c(C(F)(F)F)n1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
POLB P06746 1/20 0.56
CHRM3 P20309 7/20 0.50
NTRK1 P04629 3/20 0.46
SSTR2 P30874 1/20 0.41
STING1 Q86WV6 1/20 0.41
ATM Q13315 1/20 0.40
BACE1 P56817 2/20 0.40
BACE2 Q9Y5Z0 2/20 0.40
WDR5 P61964 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL302840 0.94 LMNA (0.60) LMNAPOLBCHRM3NTRK1SSTR2
SCHEMBL302383 0.93 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL374213 0.89 LMNA (0.56) LMNAPOLBNTRK1STING1ATM
SCHEMBL303184 0.88 LMNA (0.58) LMNAPOLBCHRM3NTRK1
SCHEMBL4918010 0.87 LMNA (0.51) LMNAPOLBCHRM3NTRK1SSTR2
SCHEMBL303104 0.87 LMNA (0.51) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL4920459 0.87 LMNA (0.51) LMNAPOLBCHRM3NTRK1SSTR2
SCHEMBL14578046 0.87 LMNA (0.68) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL373929 0.86 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL29688585 0.86 LMNA (0.52) LMNAPOLBCHRM3NTRK1STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090042725-A1 Fungicidal Mixtures Based on 3,5-Disubstituted N-Biphenyl-Pyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-02-12 US claimed
US-20090042725-A1 Fungicidal Mixtures Based on 3,5-Disubstituted N-Biphenyl-Pyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042725-A1 Fungicidal Mixtures Based on 3,5-Disubstituted N-Biphenyl-Pyrazolcarboxamides CBR3, CBR1, STS LMNA 3397/4885POLB 4048/4885CHRM3 328/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.