Sugi Predict

Sugi Predict / Compounds / SCHEMBL4920751

SCHEMBL4920751

SCHEMBL4920751

C[C@H](NC(=O)Cc1ccc(F)c(F)c1)C(=O)Nc1ncc(-c2ccccc2COC2CCCCC2)s1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNE1 P24864 5/20 0.37
▸ CDK2 P24941 5/20 0.37
▸ CDK5 Q00535 5/20 0.37
▸ CSNK2A2 P19784 2/20 0.37
▸ CSNK2A1 P68400 2/20 0.37
▸ CACNA1H O95180 2/20 0.36
▸ PSEN1 P49768 4/20 0.35
▸ PSEN2 P49810 4/20 0.35
▸ APH1B Q8WW43 4/20 0.35
▸ NCSTN Q92542 4/20 0.35
▸ APH1A Q96BI3 4/20 0.35
▸ PSENEN Q9NZ42 4/20 0.35
▸ CTSD P07339 1/20 0.35
▸ GLS O94925 1/20 0.35
▸ LIMK1 P53667 1/20 0.35
▸ DRD4 P21917 1/20 0.34
▸ TMEM97 Q5BJF2 1/20 0.34
▸ SIGMAR1 Q99720 1/20 0.34
▸ CDK5R1 Q15078 1/20 0.34
▸ CACNA1G O43497 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4922794 0.92 CCNE1 (0.41) CCNE1CDK2CDK5CSNK2A2CSNK2A1
SCHEMBL4920508 0.91 PSEN1 (0.40) CCNE1CDK2CDK5PSEN1PSEN2
SCHEMBL4914553 0.91 PSEN1 (0.44) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL4914753 0.91 PSEN1 (0.44) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL4918672 0.91 PSEN1 (0.44) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL4921373 0.90 PSEN1 (0.45) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL4923046 0.90 CCNE1 (0.47) CCNE1CDK2CDK5CSNK2A2CSNK2A1
SCHEMBL4922081 0.90 MAPT (0.45) CCNE1CDK2CDK5CSNK2A2CSNK2A1
SCHEMBL4911452 0.89 CCNE1 (0.41) CCNE1CDK2CDK5CSNK2A2CSNK2A1
SCHEMBL4921395 0.89 CCNE1 (0.40) CCNE1CDK2CDK5CSNK2A2CSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080058380-A1 ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SANOFI-AVENTIS (FR) 2008-03-06 — — US disclosed
US-7288659-B2 Acylaminothiazole derivatives, their preparation and therapeutic use SANOFI-AVENTIS (FR) 2007-10-30 — — US disclosed
EP-1417189-B1 ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE SANOFI AVENTIS (FR) 2005-12-14 — — EP disclosed
US-20040171643-A1 Acylaminothiazole derivatives, their preparation and therapeutic use SANOFI (FR) 2004-09-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080058380-A1 ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE PARK7, ACAT1, APP CCNE1 57/4885CDK2 128/4885CDK5 176/4885
US-20040171643-A1 Acylaminothiazole derivatives, their preparation and therapeutic use H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR3, CBR1 CCNE1 573/4885CDK2 2001/4885CDK5 2480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.