Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4929908 | 0.92 | PDE4B (0.42) | PDE4BCXCR2CSF1RKCNH2MAP4K1 | |
| SCHEMBL4928787 | 0.89 | PDE4B (0.55) | PDE4BCSF1RCYP3A4CYP2C9EED | |
| SCHEMBL4928496 | 0.88 | PDE4B (0.54) | PDE4BCSF1RKCNH2CYP3A4CYP2C9 | |
| SCHEMBL4928653 | 0.88 | PDE4B (0.54) | PDE4BCSF1RCYP3A4CYP2C9EED | |
| Trifluoroacetic Acid SCHEMBL4925209 | 0.88 | PDE4B (0.46) | PDE4BCSF1RCYP3A4CYP2C9EED | |
| Trifluoroacetic Acid SCHEMBL4930138 | 0.88 | PDE4B (0.45) | PDE4BCYP3A4CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL4920920 | 0.84 | PDE4B (0.45) | PDE4BCSF1RKCNH2SCN5AMAP4K1 | |
| SCHEMBL4928534 | 0.84 | PDE4B (0.59) | PDE4BCSF1RCYP3A4CYP2C9EED | |
| Trifluoroacetic Acid SCHEMBL4929976 | 0.84 | PDE4B (0.51) | PDE4BCSF1RCYP3A4CYP2C9EED | |
| SCHEMBL4930190 | 0.83 | PDE4B (0.52) | PDE4BCSF1RMAP4K1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | claimed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | PDE4A, PDE3B, PDE4B | PDE4B 3/4885CXCR2 787/4885CSF1R 4095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.