Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | ATR | Q13535 | 6/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | BRD2 | P25440 | 2/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4920764 | 0.88 | PDE4B (0.49) | PDE4BCYP3A4CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL4920920 | 0.87 | PDE4B (0.45) | PDE4BMAP4K4PDE4APDE4CPDE4D | |
| Trifluoroacetic Acid SCHEMBL4929251 | 0.85 | PDE4B (0.48) | PDE4BCYP3A4CYP2C9BRD4BRD2 | |
| Trifluoroacetic Acid SCHEMBL4925209 | 0.84 | PDE4B (0.46) | PDE4BCYP3A4CYP2C9BRD4BRD2 | |
| SCHEMBL4928787 | 0.84 | PDE4B (0.55) | PDE4BCYP3A4CYP2C9BRD4BRD2 | |
| SCHEMBL4928653 | 0.83 | PDE4B (0.54) | PDE4BCYP3A4CYP2C9BRD4BRD2 | |
| SCHEMBL4928496 | 0.83 | PDE4B (0.54) | PDE4BCYP3A4CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL4929976 | 0.83 | PDE4B (0.51) | PDE4BCYP3A4CYP2C9BRD4BRD2 | |
| Trifluoroacetic Acid SCHEMBL4929908 | 0.82 | PDE4B (0.42) | PDE4BCYP3A4CYP2C9TYK2JAK3 | |
| SCHEMBL4930190 | 0.82 | PDE4B (0.52) | PDE4BCYP3A4CYP2C9BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | claimed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | PDE4A, PDE3B, PDE4B | PDE4B 3/4885ATR 3788/4885MAP4K4 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.