Sugi Predict

Sugi Predict / Compounds / SCHEMBL4930190

SCHEMBL4930190

SCHEMBL4930190

Cc1nc(C(=O)N2CC(C)OC(C)C2)cc2c(Nc3cccc4c3CCO4)c(C(N)=O)cnc12

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 3/20 0.52
▸ CAMK1D Q8IU85 1/20 0.38
▸ CSF1R P07333 5/20 0.35
▸ MTNR1B P49286 1/20 0.35
▸ EED O75530 1/20 0.34
▸ RBBP4 Q09028 1/20 0.34
▸ SUZ12 Q15022 1/20 0.34
▸ EZH2 Q15910 1/20 0.34
▸ AEBP2 Q6ZN18 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ CYP2C9 P11712 2/20 0.34
▸ BRD4 O60885 2/20 0.34
▸ BRD2 P25440 2/20 0.34
▸ BRD3 Q15059 2/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.33
▸ BTK Q06187 1/20 0.33
▸ MAP4K1 Q92918 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4928787 0.89 PDE4B (0.55) PDE4BCSF1RMTNR1BEEDRBBP4
SCHEMBL4928653 0.89 PDE4B (0.54) PDE4BCSF1RMTNR1BEEDRBBP4
SCHEMBL4928496 0.89 PDE4B (0.54) PDE4BCAMK1DCSF1RMTNR1BEED
SCHEMBL5399007 0.87 PDE4B (0.53) PDE4BCAMK1DCSF1RMTNR1BBRD4
SCHEMBL4928534 0.86 PDE4B (0.59) PDE4BCSF1RMTNR1BEEDRBBP4
SCHEMBL4924230 0.84 PDE4B (0.57) PDE4BCSF1RMTNR1BCYP3A4CYP2C9
Trifluoroacetic Acid SCHEMBL4920764 0.83 PDE4B (0.49) PDE4BCSF1REEDRBBP4SUZ12
Trifluoroacetic Acid SCHEMBL4930138 0.82 PDE4B (0.45) PDE4BCYP3A4CYP2C9BRD4BRD2
SCHEMBL4923595 0.82 PDE4B (0.53) PDE4BCSF1RMTNR1BCYP3A4CYP2C9
SCHEMBL4299675 0.82 PDE4B (0.60) PDE4BCSF1RMTNR1BCYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080146563-A1 1,7-Naphthyridines as Pde4 Inhibitors GLAXO GROUP LIMITED 2008-06-19 — — US claimed
US-20080146563-A1 1,7-Naphthyridines as Pde4 Inhibitors GLAXO GROUP LIMITED 2008-06-19 — — US disclosed
US-20080146563-A1 1,7-Naphthyridines as Pde4 Inhibitors GLAXO GROUP LIMITED 2008-06-19 — — US disclosed
US-20080146563-A1 1,7-Naphthyridines as Pde4 Inhibitors GLAXO GROUP LIMITED 2008-06-19 — — US disclosed
EP-1866305-A1 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS GLAXO GROUP LIMITED (GB) 2007-12-19 — — EP disclosed
WO-2006097340-A1 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS GLAXO GROUP LIMITED (GB) 2006-09-21 — — WO disclosed
WO-2006097340-A1 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS GLAXO GROUP LIMITED (GB) 2006-09-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080146563-A1 1,7-Naphthyridines as Pde4 Inhibitors PDE4A, PDE3B, PDE4B PDE4B 3/4885CAMK1D 2433/4885CSF1R 4095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.