Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134737 | 0.81 | USP2 (0.59) | USP2CHEK1MLYCD | |
| SCHEMBL4660381 | 0.80 | ROCK2 (0.51) | ROCK2GPR119 | |
| SCHEMBL17442798 | 0.78 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL5254053 | 0.77 | USP2 (0.64) | USP2MLYCD | |
| SCHEMBL4661555 | 0.77 | HRH3 (0.50) | ROCK2GPR119HRH3 | |
| SCHEMBL26131028 | 0.75 | HRH3 (0.48) | ROCK2GPR119HRH3 | |
| SCHEMBL26130746 | 0.75 | HRH3 (0.54) | ROCK2GPR119HRH3 | |
| SCHEMBL3400582 | 0.75 | GPR119 (0.52) | ROCK2GPR119HRH3 | |
| Hydrochloric Acid SCHEMBL6132927 | 0.74 | USP2 (0.60) | USP2MLYCD | |
| SCHEMBL4630995 | 0.74 | ROCK2 (0.46) | ROCK2GPR119HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933832-A2 | PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | Astex Therapeutics Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2006136837-A2 | PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |