⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4921513 | 0.85 | MAPK1 (0.38) | — | |
| SCHEMBL4922621 | 0.84 | LTA4H (0.37) | — | |
| SCHEMBL4915949 | 0.81 | — | — | |
| SCHEMBL4922826 | 0.81 | CYP1A2 (0.38) | — | |
| SCHEMBL4911922 | 0.77 | CHRM1 (0.35) | — | |
| SCHEMBL4922829 | 0.74 | ALDH1A1 (0.42) | — | |
| SCHEMBL4915970 | 0.71 | — | — | |
| SCHEMBL27710807 | 0.71 | ALDH1A1 (0.47) | — | |
| SCHEMBL3011707 | 0.70 | LTA4H (0.41) | — | |
| SCHEMBL4915883 | 0.70 | KDM4E (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PFIZER INC. | 2008-08-21 | — | — | US | disclosed |
| EP-1866317-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103555-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-10-05 | — | — | WO | disclosed |