Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916310 | 0.87 | HRH4 (0.42) | F10HRH4HRH3HTTALDH1A1 | |
| SCHEMBL4919190 | 0.86 | F10 (0.42) | F10HRH4HRH3HTTALDH1A1 | |
| SCHEMBL4920927 | 0.85 | OPRM1 (0.39) | SMN1; SMN2F10HRH4HRH3AVPR2 | |
| SCHEMBL4921679 | 0.85 | POLB (0.42) | SMN1; SMN2F10HRH4HRH3ALDH1A1 | |
| SCHEMBL4915089 | 0.84 | F10 (0.40) | SMN1; SMN2F10HRH4HRH3ALDH1A1 | |
| SCHEMBL4925817 | 0.84 | F10 (0.40) | SMN1; SMN2F10HRH4HRH3CNR1 | |
| SCHEMBL4919523 | 0.83 | CYP11B2 (0.41) | MAPTKMT2ANPC1POLB | |
| SCHEMBL14281187 | 0.83 | F10 (0.39) | F10HRH4HRH3HTTALDH1A1 | |
| SCHEMBL4917951 | 0.82 | F10 (0.39) | SMN1; SMN2F10HRH4HRH3CNR1 | |
| SCHEMBL4921955 | 0.82 | F10 (0.38) | SMN1; SMN2F10HRH4HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015178-A1 | BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS MEDICAMENT | GERLACH KAI | 2008-01-17 | — | — | US | claimed |
| US-20050272792-A1 | Benzimidazoles, process for their preparation and use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-08 | — | — | US | claimed |
| US-20080015178-A1 | BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS MEDICAMENT | GERLACH KAI | 2008-01-17 | — | — | US | disclosed |
| US-20080015178-A1 | BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS MEDICAMENT | GERLACH KAI | 2008-01-17 | — | — | US | disclosed |
| US-20080015178-A1 | BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS MEDICAMENT | GERLACH KAI | 2008-01-17 | — | — | US | disclosed |
| US-20050272792-A1 | Benzimidazoles, process for their preparation and use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272792-A1 | Benzimidazoles, process for their preparation and use thereof as medicament | CYP2C19, CYP3A4, CYP2B6 | NPY2R 2991/4885SMN1; SMN2 2595/4885F10 3212/4885 |
| US-20080015178-A1 | BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS MEDICAMENT | CYP2C19, CYP3A4, CYP2B6 | NPY2R 2991/4885SMN1; SMN2 2595/4885F10 3212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.