Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262018 | 0.87 | EPHX2 (0.52) | EPHX2EPHX1KMT2AALDH1A1HTT | |
| SCHEMBL2934918 | 0.85 | ALDH1A1 (0.47) | KMT2AALDH1A1MAPK1HPGDMAPT | |
| SCHEMBL2935066 | 0.82 | NPC1 (0.51) | EPHX2EPHX1ALDH1A1MAPK1HTT | |
| SCHEMBL3225753 | 0.72 | EPHX1 (0.49) | EPHX1KMT2AALDH1A1HTTKDM4E | |
| SCHEMBL3224621 | 0.70 | PTPN1 (0.47) | ALDH1A1HPGDMAPTHSD17B10KDM4E | |
| SCHEMBL3204480 | 0.70 | EPHX1 (0.50) | EPHX2EPHX1KMT2AHPGDTP53 | |
| Carbamic Acid SCHEMBL4557656 | 0.69 | SMN1; SMN2 (0.39) | EPHX2EPHX1KMT2AALDH1A1TP53 | |
| SCHEMBL3224451 | 0.69 | PTPN1 (0.54) | — | |
| SCHEMBL3219608 | 0.69 | PTPN1 (0.54) | — | |
| SCHEMBL3220566 | 0.69 | TRPV1 (0.47) | HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067527-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2008-06-05 | — | — | WO | disclosed |