Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 16/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.53 |
| ▸ | TSHR | P16473 | 14/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.53 |
| ▸ | LMNA | P02545 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.48 |
| ▸ | USP2 | O75604 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923082 | 0.92 | APLNR (0.52) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL4925226 | 0.87 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL4918798 | 0.86 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL15400259 | 0.73 | APLNR (0.61) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL30908321 | 0.73 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL10845668 | 0.72 | KDM4E (0.41) | CYP1A2CYP3A4CYP2C19LMNAMAPT | |
| SCHEMBL31123781 | 0.72 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL21682074 | 0.72 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL2460445 | 0.72 | JAK2 (0.60) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL319769 | 0.71 | APLNR (0.58) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598173-B2 | 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives for treating tumors | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2013-12-03 | — | — | US | disclosed |
| US-20130053390-A1 | 1-[(6,7-SUBSTITUTED ALKOXYQUINOXALINYL)AMINOCARBONYL]-4-(HETERO)ARYLPIPERAZINE DERIVATIVES | REXAHN PHARMACEUTICALS, INC. | 2013-02-28 | — | — | US | disclosed |
| US-8314100-B2 | 1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives | REXAHN PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20080318963-A1 | 1-[6,7-Substituted Alkoxyquinoxalinyl) Aminocarbonyl]-4-(Hetero) Arylpiperazine Derivatives | REXAHN PHARMACEUTICALS, INC. (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1819698-A1 | 1-[(6,7-SUBSTITUTED ALKOXYQUINOXALINYL)AMINOCARBONYL]-4-(HETERO)ARYLPIPERAZINE DERIVATIVES | Rexahn Pharmaceuticals, Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006054830-A1 | 1-[(6,7-SUBSTITUTED ALKOXYQUINOXALINYL)AMINOCARBONYL]-4-(HETERO)ARYLPIPERAZINE DERIVATIVES | REXAHN PHARMACEUTICALS, INC. (US) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318963-A1 | 1-[6,7-Substituted Alkoxyquinoxalinyl) Aminocarbonyl]-4-(Hetero) Arylpiperazine Derivatives | HRAS, CDK4, KRAS | CYP1A2 896/4885CYP3A4 1237/4885CYP2C19 2977/4885 |
| US-20130053390-A1 | 1-[(6,7-SUBSTITUTED ALKOXYQUINOXALINYL)AMINOCARBONYL]-4-(HETERO)ARYLPIPERAZINE DERIVATIVES | HRAS, CDK4, KRAS | CYP1A2 668/4885CYP3A4 965/4885CYP2C19 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.