SCHEMBL4927293

SCHEMBL4927293

O=c1ccc2ccc(S(=O)(=O)C(F)(F)F)cc2o1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 9/20 0.47
CA1 P00915 8/20 0.47
CA9 Q16790 8/20 0.47
ALDH1A1 P00352 5/20 0.47
KDM4E B2RXH2 5/20 0.47
GLA P06280 4/20 0.47
HSD17B10 Q99714 4/20 0.47
MCL1 Q07820 4/20 0.47
GAA P10253 3/20 0.47
AKR1B1 P15121 3/20 0.47
HPGD P15428 3/20 0.47
CASP1 P29466 2/20 0.47
CASP7 P55210 2/20 0.47
ERAP1 Q9NZ08 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
STS P08842 1/20 0.46
MAOB P27338 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethanesulfonic Acid SCHEMBL3367262 0.78 CA12 (0.42) CA12CA1CA9ALDH1A1KDM4E
SCHEMBL5866740 0.77 CA12 (0.52) CA12CA1CA9ALDH1A1KDM4E
SCHEMBL5866898 0.77 GLA (0.58) CA12CA1CA9ALDH1A1KDM4E
SCHEMBL3521815 0.76 MAOB (0.52) CA12CA1CA9ALDH1A1KDM4E
SCHEMBL1990745 0.75 ALDH1A1 (0.47) ALDH1A1KDM4EGLAHSD17B10HPGD
SCHEMBL9432106 0.74 GLA (0.68) CA12CA1CA9ALDH1A1KDM4E
SCHEMBL3517958 0.74 CA12 (0.48) CA12CA1CA9ALDH1A1KDM4E
SCHEMBL7197925 0.74 ALDH1A1 (0.59) ALDH1A1MEN1KMT2ALMNASMN1; SMN2
Hydrogen Sulfide SCHEMBL6878856 0.73 GLA (0.66) CA12CA1CA9ALDH1A1KDM4E
Trifluoromethanesulfonic Acid SCHEMBL5114458 0.73 GLA (0.50) CA12CA1CA9ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120518572-A Hydrogen sulfide fluorescent probe based on naphthyridine coumarin and preparation and application thereof 贺州学院 2025-08-22 CN disclosed
CN-120518598-A Copper ion ratio fluorescent probe based on naphthyridine coumarin and preparation and application thereof 贺州学院 2025-08-22 CN disclosed
US-20150125904-A1 PROBE INCORPORATION MEDIATED BY ENZYMES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2015-05-07 US disclosed
WO-2013148189-A1 PROBE INCORPORATION MEDIATED BY ENZYMES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-10-03 WO disclosed
US-20080194522-A1 Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE 2008-08-14 US disclosed
WO-2006026368-A2 DEVELOPMENT OF FLUOROGENIC SUBSTRATES FOR MONOAMINE OXIDASES (MAO-A AND MAO-B) THE TRUSTEES OF COLLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2006-03-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080194522-A1 Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) MAOA, MAOB, COMT CA12 3628/4885CA1 1732/4885CA9 2007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.