Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928110 | 0.86 | NPC1 (0.45) | ADORA2AADORA3LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2704466 | 0.72 | KCNN4 (0.54) | LMNAGAAALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL14933443 | 0.72 | SMN1; SMN2 (0.53) | LMNAALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL23402655 | 0.67 | NPC1 (0.47) | LMNAGAAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7852486 | 0.64 | PTGS2 (0.57) | LMNAGAAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL11829511 | 0.63 | RAB9A (0.42) | ADORA2ALMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL22997125 | 0.63 | NPC1 (0.61) | LMNAGAAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL21539292 | 0.63 | NPC1 (0.50) | LMNAGAAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29842935 | 0.62 | DRD4 (0.55) | LMNAALDH1A1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL3428661 | 0.62 | NPC1 (0.61) | LMNAGAASMN1; SMN2HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021056-A1 | Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021056-A1 | Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase | BACE1, BACE2, PSEN1 | ADORA2A 3259/4885ADORA3 2779/4885LMNA 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.