Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072739 | 0.85 | HSD17B10 (0.34) | NPSR1ITGB1ITGA5CHRNB2CHRNB4 | |
| SCHEMBL4064831 | 0.82 | PDE10A (0.38) | NPSR1PDE10AITGB1ITGA5KCNH2 | |
| SCHEMBL8234289 | 0.82 | PAX8 (0.36) | NPSR1 | |
| SCHEMBL4065110 | 0.79 | NPSR1 (0.36) | NPSR1PDE10A | |
| SCHEMBL4071519 | 0.78 | KCNH2 (0.40) | NPSR1PDE10AITGB1ITGA5KCNH2 | |
| SCHEMBL4073680 | 0.77 | NPSR1 (0.35) | NPSR1PDE10A | |
| SCHEMBL4072992 | 0.71 | ALDH1A1 (0.34) | NPSR1ITGB1ITGA5 | |
| SCHEMBL4064446 | 0.71 | NPSR1 (0.54) | NPSR1KCNH2 | |
| SCHEMBL4720183 | 0.70 | — | — | |
| SCHEMBL5712482 | 0.70 | SMN1; SMN2 (0.41) | NPSR1KCNH2NOS1NOS2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ITGB5, ITGB1, ITGA2B | NPSR1 943/4885PDE10A 2029/4885EDNRB 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.