Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.55 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494898 | 0.85 | HTT (0.73) | HTTSMN1; SMN2NPC1LMNATDP1 | |
| SCHEMBL6884651 | 0.85 | PTGS1 (0.67) | HTTSMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL19091783 | 0.84 | SMN1; SMN2 (0.57) | HTTSMN1; SMN2NPC1LMNAALDH1A1 | |
| SCHEMBL3369060 | 0.83 | HTT (0.76) | HTTSMN1; SMN2NPC1LMNATDP1 | |
| SCHEMBL10684986 | 0.83 | HTT (0.76) | HTTSMN1; SMN2NPC1LMNATDP1 | |
| SCHEMBL14271130 | 0.83 | HTT (0.55) | HTTSMN1; SMN2NPC1LMNATDP1 | |
| SCHEMBL4510673 | 0.83 | SMN1; SMN2 (0.57) | HTTSMN1; SMN2LMNATDP1ALDH1A1 | |
| SCHEMBL17054176 | 0.82 | ALDH1A1 (0.67) | HTTSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL3438778 | 0.82 | KDM4E (0.72) | HTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3369054 | 0.81 | HTT (0.73) | HTTSMN1; SMN2NPC1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045726-A1 | Spirolactams and Their Synthesis | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-02-21 | — | — | US | disclosed |
| US-20080045726-A1 | Spirolactams and Their Synthesis | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-02-21 | — | — | US | disclosed |
| US-7291728-B2 | Spirolactams and their synthesis | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2007-11-06 | — | — | US | disclosed |
| US-7291728-B2 | Spirolactams and their synthesis | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2007-11-06 | — | — | US | disclosed |
| EP-1771410-A1 | SPIROLACTAMS AND THEIR SYNTHESIS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-04-11 | — | — | EP | disclosed |
| WO-2005108356-A1 | SPIROLACTAMS AND THEIR SYNTHESIS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-11-17 | — | — | WO | disclosed |
| EP-1595865-A1 | New spirolactams and their synthesis | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-11-16 | — | — | EP | disclosed |
| US-20050250759-A1 | Spirolactams and their synthesis | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045726-A1 | Spirolactams and Their Synthesis | VKORC1, VKORC1L1, DHPS | HTT 4166/4885SMN1; SMN2 4635/4885NPC1 2503/4885 |
| US-20050250759-A1 | Spirolactams and their synthesis | VKORC1, DHPS, SRI | HTT 3079/4885SMN1; SMN2 4533/4885NPC1 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.