Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 11/20 | 0.44 |
| ▸ | AKT1 | P31749 | 10/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1791682 | 0.94 | RPS6KB1 (0.44) | RPS6KB1AKT1LRRK2TDP1KDM4E | |
| SCHEMBL1791664 | 0.89 | RPS6KB1 (0.44) | RPS6KB1AKT1LRRK2KDM4ESMN1; SMN2 | |
| SCHEMBL1788327 | 0.88 | KDM4E (0.42) | RPS6KB1AKT1LRRK2KDM4EKIT | |
| SCHEMBL4928639 | 0.86 | LTA4H (0.45) | RPS6KB1AKT1SMN1; SMN2TNK2MEN1 | |
| SCHEMBL1791899 | 0.84 | USP2 (0.43) | RPS6KB1AKT1LRRK2KDM4EFLT3 | |
| SCHEMBL1792161 | 0.82 | RPS6KB1 (0.41) | RPS6KB1AKT1LRRK2KDM4ESMN1; SMN2 | |
| SCHEMBL1790594 | 0.82 | RPS6KB1 (0.41) | RPS6KB1AKT1TNK2MEN1KMT2A | |
| SCHEMBL1791763 | 0.81 | RPS6KB1 (0.42) | RPS6KB1AKT1LRRK2KDM4ESMN1; SMN2 | |
| SCHEMBL1792648 | 0.81 | RPS6KB1 (0.42) | RPS6KB1AKT1LRRK2ESR1ESR2 | |
| SCHEMBL1793930 | 0.80 | LTA4H (0.45) | RPS6KB1AKT1TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080076774-A1 | Kinase Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | AKT3, RPS6KA3, CDK3 | RPS6KB1 13/4885AKT1 6/4885LRRK2 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.