Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 10/20 | 0.43 |
| ▸ | AKT1 | P31749 | 9/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | FECH | P22830 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793930 | 0.94 | LTA4H (0.45) | LTA4HBACE1RPS6KB1AKT1MAP4K4 | |
| SCHEMBL4928646 | 0.86 | RPS6KB1 (0.44) | RPS6KB1AKT1TNK2MEN1LMNA | |
| SCHEMBL1793737 | 0.84 | DRD2 (0.45) | LTA4HBACE1RPS6KB1AKT1MAP4K4 | |
| SCHEMBL1791682 | 0.80 | RPS6KB1 (0.44) | RPS6KB1AKT1TNK2SMN1; SMN2 | |
| SCHEMBL1790594 | 0.79 | RPS6KB1 (0.41) | RPS6KB1AKT1TNK2MEN1KMT2A | |
| SCHEMBL1790616 | 0.77 | RPS6KB1 (0.45) | RPS6KB1AKT1MEN1LMNAMAPT | |
| SCHEMBL1793570 | 0.76 | RPS6KB1 (0.69) | RPS6KB1AKT1LMNAMAPTHTT | |
| SCHEMBL1787788 | 0.76 | RPS6KB1 (0.49) | RPS6KB1AKT1LMNAMAPTHTT | |
| SCHEMBL1791664 | 0.75 | RPS6KB1 (0.44) | RPS6KB1AKT1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1789775 | 0.75 | RPS6KB1 (0.68) | RPS6KB1AKT1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080076774-A1 | Kinase Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | AKT3, RPS6KA3, CDK3 | LTA4H 3953/4885BACE1 1380/4885RPS6KB1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.