Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924499 | 1.00 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6ROCK1 | |
| SCHEMBL4925329 | 0.88 | ROCK1 (0.52) | HDAC3HDAC4HDAC1HDAC6ROCK1 | |
| SCHEMBL4929103 | 0.87 | ROCK1 (0.48) | HDAC3HDAC4HDAC1HDAC6ROCK1 | |
| SCHEMBL4927755 | 0.85 | ROCK1 (0.52) | ROCK1AKT3ALDH1A1HPGDSKDM4E | |
| SCHEMBL4931327 | 0.85 | ROCK1 (0.52) | ROCK1AKT3ALDH1A1HPGDSKDM4E | |
| SCHEMBL4929158 | 0.85 | ROCK1 (0.70) | ROCK1CHEK1AURKAMAP4K4PRKACA | |
| SCHEMBL4927771 | 0.85 | ROCK1 (0.70) | ROCK1CHEK1AURKAMAP4K4PRKACA | |
| SCHEMBL4923121 | 0.85 | ROCK1 (0.70) | ROCK1CHEK1AURKAMAP4K4PRKACA | |
| SCHEMBL13992686 | 0.84 | AKT3 (0.52) | AKT3MAPTCDC7LMNA | |
| SCHEMBL4990803 | 0.84 | AKT3 (0.52) | AKT3MAPTCDC7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| EP-1708697-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-11-28 | — | — | EP | disclosed |
| EP-1708697-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005074642-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293716-A1 | Chemical Compounds | CYP11B2, CYP11B1, REN | HDAC3 201/4885HDAC4 943/4885HDAC1 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.