Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.75 |
| ▸ | L3MBTL3 | Q96JM7 | 9/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.55 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.55 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938741 | 0.86 | HRH3 (0.58) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4138929 | 0.86 | HRH3 (0.58) | HRH3L3MBTL3L3MBTL1KDM4EPOLB | |
| SCHEMBL2846135 | 0.86 | HRH3 (1.00) | HRH3L3MBTL3L3MBTL1KDM4EPOLB | |
| SCHEMBL2844224 | 0.83 | HRH3 (0.93) | HRH3L3MBTL3L3MBTL1KDM4EPOLB | |
| SCHEMBL10726916 | 0.82 | KDM4E (0.94) | HRH3L3MBTL3L3MBTL1KDM4EPOLB | |
| SCHEMBL4147049 | 0.81 | L3MBTL3 (0.67) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL10293557 | 0.80 | L3MBTL3 (1.00) | L3MBTL3L3MBTL1KDM4EPOLBALDH1A1 | |
| SCHEMBL4130681 | 0.80 | L3MBTL3 (0.66) | HRH3L3MBTL3L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL4139958 | 0.80 | L3MBTL3 (0.66) | HRH3L3MBTL3L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10293600 | 0.80 | KDM4E (0.79) | HRH3L3MBTL3L3MBTL1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | claimed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | HRH3, HRH4, HRH1 | HRH3 1/4885L3MBTL3 2655/4885L3MBTL1 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.