Pirifibrate

Pirifibrate

SCHEMBL49309

CC(C)(Oc1ccc(Cl)cc1)C(=O)OCc1cccc(CO)n1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.58
PPARA Q07869 5/20 0.58
CYP3A4 P08684 5/20 0.58
ABCB11 O95342 2/20 0.58
TSHR P16473 2/20 0.58
HTR2A P28223 2/20 0.58
PMP22 Q01453 2/20 0.58
CYP2C19 P33261 5/20 0.47
KMT2A Q03164 4/20 0.47
MEN1 O00255 3/20 0.47
MAPT P10636 2/20 0.47
CYP2D6 P10635 2/20 0.47
ALDH1A1 P00352 4/20 0.46
HPGD P15428 2/20 0.46
MRGPRX4 Q96LA9 1/20 0.44
CYP2C9 P11712 4/20 0.43
PPARG P37231 2/20 0.43
USP2 O75604 1/20 0.43
LMNA P02545 1/20 0.43
ADORA3 P0DMS8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pirifibrate SCHEMBL29847912 1.00 CYP1A2 (0.58) CYP1A2PPARACYP3A4ABCB11TSHR
SCHEMBL11867956 0.87 CYP1A2 (0.54) CYP1A2PPARACYP3A4ABCB11TSHR
SCHEMBL27776499 0.76 PPARA (0.66) CYP1A2PPARACYP3A4ABCB11TSHR
Clofibrate SCHEMBL28086141 0.74 PPARA (0.94) CYP1A2PPARACYP3A4ABCB11TSHR
SCHEMBL11641659 0.74 PPARA (0.72) CYP1A2PPARACYP3A4ABCB11TSHR
Clofibrate SCHEMBL3953607 0.74 PPARA (1.00) CYP1A2PPARACYP3A4ABCB11TSHR
Clofibrate SCHEMBL2356 0.74 PPARA (1.00) CYP1A2PPARACYP3A4ABCB11TSHR
SCHEMBL11431131 0.74 PPARA (0.62) CYP1A2PPARACYP3A4ABCB11TSHR
Nicofibrate SCHEMBL49182 0.73 CYP1A2 (0.58) CYP1A2PPARACYP3A4ABCB11TSHR
Clofibrate SCHEMBL11184809 0.73 PPARA (0.97) CYP1A2PPARACYP3A4ABCB11TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1758 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS INC (US) 2026-04-23 US claimed
US-20250367216-A1 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY INTERCEPT PHARMACEUTICALS INC (US) 2025-12-04 US claimed
US-20250367217-A1 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY INTERCEPT PHARMACEUTICALS INC (US) 2025-12-04 US claimed
US-20240300907-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-09-12 US claimed
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-12 US claimed
US-20230159474-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2023-05-25 US claimed
US-11643399-B2 Modulators of mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-05-09 US claimed
US-20230053860-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2023-02-23 US claimed
EP-4135691-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2023-02-22 EP claimed
US-20230008367-A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES ABIONYX PHARMA SA (FR) 2023-01-12 US claimed
EP-0687172-B1 SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF PHARMACIA AB (SE) 2002-12-04 EP claimed
US-6211207-B1 ANTIDIABETIC AGENTS AND INSULIN SENSITIVITY ENHANCER TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US claimed
US-6211206-B1 Pharmaceutical composition TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US claimed
US-6207178-B1 STABLE SUSPENSION KABI PHARMACIA AB (SE) 2001-03-27 US claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
US-6133293-A INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH OTHER ANTIDIABETICS DIFFERING FROM THE ENHANCER IN THE MECHANISM OF ACTION; POTENT DEPRESSIVE EFFECT ON DIABETIC HYPERGLYCEMIA; 2,4-THIAZOLIDINEDIONES AND OXAZOLIDINEDIONES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-10-17 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-5785976-A Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof PHARMACIA & UPJOHN AB (SE) 1998-07-28 US claimed
EP-0687172-A1 SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF Pharmacia & Upjohn Aktiebolag (SE) 1995-12-20 EP claimed
WO-1994020072-A1 SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF PHARMACIA AB (SE) 1994-09-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods MRGPRX4, MRGPRX1, MRGPRX2 CYP1A2 2025/4885PPARA 1378/4885CYP3A4 826/4885
US-11643399-B2 Modulators of mas-related G-protein receptor X4 and related products and methods MRGPRX4, MRGPRX1, MRGPRX2 CYP1A2 2025/4885PPARA 1378/4885CYP3A4 826/4885
US-20250367216-A1 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY PPARD, NR1H4, PPARG CYP1A2 397/4885PPARA 4/4885CYP3A4 415/4885
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 CYP1A2 1885/4885PPARA 1336/4885CYP3A4 822/4885
US-20250367217-A1 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY PPARD, NR1H4, PPARG CYP1A2 397/4885PPARA 4/4885CYP3A4 415/4885
US-20230159474-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 CYP1A2 2025/4885PPARA 1378/4885CYP3A4 826/4885
US-20240300907-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 CYP1A2 2025/4885PPARA 1378/4885CYP3A4 826/4885
US-20230008367-A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES SLC10A1, CPT1A, CES1 CYP1A2 353/4885PPARA 27/4885CYP3A4 464/4885
US-20230053860-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 CYP1A2 2025/4885PPARA 1378/4885CYP3A4 826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.