Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxifluridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HBB | P68871 | 1/20 | 1.00 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.54 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.54 |
| ▸ | PYGM | P11217 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | TK2 | O00142 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxifluridine SCHEMBL28690558 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL10079621 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL14291576 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL8094 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL14564897 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL12932255 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL98005 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL8095 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL15060572 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 | |
| Doxifluridine SCHEMBL13300971 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2MAPTTSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080241068-A1 | SYSTEM AND METHODS FOR IDENTIFYING INDIVIDUALS AT RISK FOR SYSTEMIC FLUOROPYRIMIDINE TOXICITY | COHEN JAMES M | 2008-10-02 | — | — | US | disclosed |