Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23494075 | 0.84 | TSHR (0.44) | TSHRTHRBFAAHCA2CA1 | |
| SCHEMBL28090040 | 0.81 | TSHR (0.42) | TSHRTHRBFAAHCA2CA1 | |
| SCHEMBL441439 | 0.80 | FAAH (0.47) | TSHRTHRBFAAHCA2CA1 | |
| SCHEMBL6673452 | 0.80 | TSHR (0.41) | TSHRTHRBFAAHCA2CA1 | |
| Hydrochloric Acid SCHEMBL8410679 | 0.80 | TSHR (0.35) | TSHRFAAHCA2CA1LMNA | |
| Hydrochloric Acid SCHEMBL28431427 | 0.79 | TSHR (0.51) | TSHRTHRBFAAHCA2LMNA | |
| SCHEMBL1577727 | 0.78 | TSHR (0.48) | TSHRTHRBFAAHCA2CA1 | |
| SCHEMBL612282 | 0.78 | TSHR (0.48) | TSHRTHRBFAAHCA2CA1 | |
| Hydrochloric Acid SCHEMBL28440817 | 0.78 | TSHR (0.50) | TSHRTHRBFAAHCA2LMNA | |
| SCHEMBL8955893 | 0.78 | TSHR (0.50) | TSHRTHRBFAAHCA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080250979-A1 | Clear Coating Composition and Clear Coating Film Formation Method | NIPPON PAINT CO., LTD. (JP) | 2008-10-16 | — | — | US | disclosed |
| EP-1735393-A4 | CLEAR COATING COMPOSITION AND CLEAR COATING FILM FORMATION METHOD | NIPPON PAINT CO LTD (JP) | 2007-09-05 | — | — | EP | disclosed |
| EP-1735393-A1 | CLEAR COATING COMPOSITION AND CLEAR COATING FILM FORMATION METHOD | Nippon Paint Co., Ltd. (JP) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005100492-A1 | CLEAR COATING COMPOSITION AND CLEAR COATING FILM FORMATION METHOD | NIPPON PAINT CO., LTD. (JP) | 2005-10-27 | — | — | WO | disclosed |