SCHEMBL4934384

SCHEMBL4934384

CCC(C)Nc1cc(C)cc(COc2c(Cl)cc(CC(F)C(=O)O)cc2Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.37
S1PR1 P21453 2/20 0.36
MRGPRX4 Q96LA9 2/20 0.35
TACR1 P25103 1/20 0.34
TSHR P16473 1/20 0.34
HPGD P15428 1/20 0.32
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
MCL1 Q07820 1/20 0.32
SLC7A5 Q01650 1/20 0.32
ALDH1A1 P00352 2/20 0.31
HTT P42858 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MME P08473 1/20 0.31
ACE P12821 1/20 0.31
CPA1 P15085 1/20 0.31
ACE2 Q9BYF1 1/20 0.31
ITGB1 P05556 1/20 0.31
ITGA4 P13612 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4931005 0.91 FFAR1 (0.37) FFAR1MRGPRX4HPGDKMT2AMEN1
SCHEMBL4935426 0.91 FFAR1 (0.39) FFAR1S1PR1MRGPRX4TACR1KMT2A
SCHEMBL4932946 0.90 MEN1 (0.40) FFAR1S1PR1KMT2AMEN1MCL1
SCHEMBL5718158 0.88 MEN1 (0.37) FFAR1S1PR1HPGDKMT2AMEN1
SCHEMBL4934220 0.87 MME (0.42) FFAR1MRGPRX4MMEACECPA1
SCHEMBL4931582 0.86 FFAR1 (0.39) FFAR1S1PR1MRGPRX4TACR1KMT2A
SCHEMBL5717725 0.86 MRGPRX4 (0.36) FFAR1S1PR1MRGPRX4KMT2AMEN1
SCHEMBL4931768 0.86 FFAR1 (0.40) FFAR1MRGPRX4TACR1KMT2ASLC7A5
SCHEMBL5111291 0.86 FFAR1 (0.37) FFAR1S1PR1MRGPRX4TACR1HPGD
SCHEMBL4932666 0.85 FFAR1 (0.38) FFAR1S1PR1MRGPRX4TACR1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080221210-A1 Thyroid Receptor Agonists KARO BIO AB (SE) 2008-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080221210-A1 Thyroid Receptor Agonists TSHR, TRHR, THRA FFAR1 37/4885S1PR1 172/4885MRGPRX4 119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.