Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 10/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320686 | 0.83 | PTGS2 (0.50) | RPS6KA3 | |
| SCHEMBL27639098 | 0.82 | USP7 (0.46) | ESR1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16982131 | 0.82 | RPS6KA3 (0.49) | SENP1ESR1RPS6KA3ESR2ABL1 | |
| SCHEMBL7077947 | 0.79 | DHODH (0.40) | CYP2C9CYP2C19RPS6KA3ESR2 | |
| SCHEMBL27928527 | 0.78 | ESR1 (0.57) | ESR1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27639192 | 0.78 | ESR1 (0.41) | ESR1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25420748 | 0.78 | RPS6KA3 (0.49) | SENP1ESR1RPS6KA3ESR2ABL1 | |
| SCHEMBL1759436 | 0.78 | ESR2 (0.47) | ESR1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9318422 | 0.77 | GCGR (0.38) | — | |
| SCHEMBL13105050 | 0.77 | ESR1 (0.56) | SENP1ESR1ESR2ABL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329777-B2 | Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis | BAYER AKTIENGESELLSCHAFT (DE) | 2008-02-12 | — | — | US | disclosed |
| US-6939990-B2 | Derivatives of dicarboxylic acid having pharmaceutical properties | BAYER AKTIENGESELLSCHAFT (DE) | 2005-09-06 | — | — | US | disclosed |