Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 7/20 | 0.61 |
| ▸ | COMT | P21964 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935211 | 1.00 | FTO (0.61) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4939974 | 0.93 | FTO (0.61) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL14185400 | 0.93 | FTO (0.61) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4939979 | 0.93 | FTO (0.61) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL14185403 | 0.92 | FTO (0.59) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4941789 | 0.91 | FTO (0.65) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4941843 | 0.91 | FTO (0.65) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4936909 | 0.91 | FTO (0.58) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4942938 | 0.91 | FTO (0.58) | FTOCOMTMEN1KMT2AABCC3 | |
| SCHEMBL4942935 | 0.91 | FTO (0.58) | FTOCOMTMEN1KMT2AABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080103191-A1 | ENTACAPONE-DERIVATIVES | SCHWARZ PHARMA AG (DE) | 2008-05-01 | — | — | US | disclosed |
| US-20080103191-A1 | ENTACAPONE-DERIVATIVES | SCHWARZ PHARMA AG (DE) | 2008-05-01 | — | — | US | disclosed |
| US-20080103191-A1 | ENTACAPONE-DERIVATIVES | SCHWARZ PHARMA AG (DE) | 2008-05-01 | — | — | US | disclosed |
| WO-2007144169-A2 | ENTACAPONE-DERIVATIVES | SCHWARZ PHARMA AG (DE) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103191-A1 | ENTACAPONE-DERIVATIVES | ENTPD5, ENTPD3, ENTPD1 | FTO 2243/4885COMT 365/4885MEN1 1023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.