Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22164008 | 0.87 | LMNA (0.65) | ALDH1A1SIGMAR1SMN1; SMN2POLBCYP3A4 | |
| SCHEMBL16054965 | 0.85 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2POLBTSHRLMNA | |
| SCHEMBL9612032 | 0.85 | POLB (0.69) | ALDH1A1SIGMAR1SMN1; SMN2POLBCYP3A4 | |
| SCHEMBL374400 | 0.79 | LMNA (0.72) | ALDH1A1SIGMAR1SMN1; SMN2POLBTSHR | |
| SCHEMBL4950181 | 0.77 | GAA (0.69) | SIGMAR1SMN1; SMN2LMNAKDM4EKMT2A | |
| SCHEMBL12717312 | 0.77 | ALDH1A1 (0.71) | ALDH1A1SIGMAR1SMN1; SMN2POLBTSHR | |
| SCHEMBL17010820 | 0.76 | ALDH1A1 (0.59) | ALDH1A1SIGMAR1SMN1; SMN2POLBTSHR | |
| SCHEMBL28088901 | 0.76 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2POLBLMNANPC1 | |
| SCHEMBL18049339 | 0.75 | ALDH1A1 (0.69) | ALDH1A1SIGMAR1SMN1; SMN2POLBTSHR | |
| SCHEMBL26358413 | 0.75 | NPC1 (0.60) | ALDH1A1SMN1; SMN2NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | RET, PRKDC, PRKACA | ALDH1A1 3290/4885SIGMAR1 4157/4885SMN1; SMN2 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.