Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Anisindione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anisindione SCHEMBL29688105 | 1.00 | RAB9A (1.00) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL6284499 | 0.85 | RAB9A (0.74) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL14939328 | 0.83 | RAB9A (0.71) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL10833433 | 0.83 | RAB9A (0.69) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL8958196 | 0.80 | RAB9A (0.67) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL6828591 | 0.78 | HPGD (0.65) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL10559578 | 0.78 | MEN1 (1.00) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL14939354 | 0.78 | RAB9A (0.63) | RAB9AMAPTNPC1TP53HPGD | |
| SCHEMBL14581389 | 0.78 | RAB9A (0.63) | RAB9AMAPTNPC1TP53HPGD | |
| Phenindione SCHEMBL33831 | 0.77 | MAPT (1.00) | RAB9AMAPTNPC1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2694 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162977-B2 | Blocked polyisocyanate crosslinking agent, its preparation method and a coating composition comprising the same | BASF COATINGS GMBH (DE) | 2024-12-10 | — | — | US | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| WO-2023230770-A1 | METHODS OF LUNG ADENOCARCINOMA TREATMENT WITH NON ANTI-LUAD DRUGS OR COMPOUNDS | Suzhou Singleron Biotechnologies Co., Ltd. (CN) | 2023-12-07 | — | — | WO | claimed |
| US-20220389153-A1 | A BLOCKED POLYISOCYANATE CROSSLINKING AGENT, ITS PREPARATION METHOD AND A COATING COMPOSITION COMPRISING THE SAME | BASF COATINGS GMBH (DE) | 2022-12-08 | — | — | US | claimed |
| EP-4058500-A1 | A BLOCKED POLYISOCYANATE CROSSLINKING AGENT, ITS PREPARATION METHOD AND A COATING COMPOSITION COMPRISING THE SAME | BASF Coatings GmbH (DE) | 2022-09-21 | — | — | EP | claimed |
| US-11318331-B2 | Pulmonary hypertension treatment | SONIVIE LTD. (IL) | 2022-05-03 | — | — | US | claimed |
| CN-114053206-A | Medicinal floating preparation and preparation method thereof | 常州恒邦药业有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-114053207-A | Sustained-release pharmaceutical composition and preparation method thereof | 常州恒邦药业有限公司 | 2022-02-18 | — | — | CN | claimed |
| US-20220008334-A1 | GASTRIC RETENTIVE DEVICES | CLEXIO BIOSCIENCES LTD. (IL) | 2022-01-13 | — | — | US | claimed |
| US-11147766-B2 | Gastric retentive devices | CLEXIO BIOSCIENCES LTD. (IL) | 2021-10-19 | — | — | US | claimed |
| WO-2002019935-A1 | METHOD AND SYSTEM FOR ANTICOAGULANT DOSE REVISION | THE RXFILES CORPORATION (US) | 2002-03-14 | — | — | WO | claimed |
| WO-2002005815-A1 | OPHTHALMIC FORMULATION OF A SELECTIVE CYCLOOXYGENASE-2 INHIBITORY DRUG | PHARMACIA & UPJOHN COMPANY (US) | 2002-01-24 | — | — | WO | claimed |
| US-20010041687-A1 | Use of flavone 8-acetic acid in vascular and cardiovascular interventions and acute coronary syndromes | MRUK JOZEF S (US) | 2001-11-15 | — | — | US | claimed |
| WO-2001052839-A1 | USE OF FLAVONE 8-ACETIC ACID IN VASCULAR AND CARDIOVASCULAR INTERVENTIONS AND ACUTE CORONARY SYNDROMES | MRUK JOZEF S (US) | 2001-07-26 | — | — | WO | claimed |
| US-5814655-A | ANTIINFLAMMATORY AGENTS FOR EYES | INSITE VISION INCORPORATED (US) | 1998-09-29 | — | — | US | claimed |
| US-5236705-A | Administering interleukin-4 | THE UNIVERSITY OF MELBOURNE (AU) | 1993-08-17 | — | — | US | claimed |
| EP-0454736-A4 | FIBRINOLYSIS | — | 1993-05-12 | — | — | EP | claimed |
| EP-0454736-A1 | FIBRINOLYSIS BY IL-4 | THE UNIVERSITY OF MELBOURNE (AU) | 1991-11-06 | — | — | EP | claimed |
| US-5023088-A | Drug delivery dispenser | ALZA CORPORATION (US) | 1991-06-11 | — | — | US | claimed |
| WO-1990007932-A1 | FIBRINOLYSIS | THE UNIVERSITY OF MELBOURNE (AU) | 1990-07-26 | — | — | WO | claimed |