Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757740 | 0.85 | KMT2A (0.45) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10169728 | 0.78 | RAB9A (0.61) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10131745 | 0.78 | NPC1 (0.53) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10132047 | 0.76 | KMT2A (0.51) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10131508 | 0.76 | ALDH1A1 (0.51) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10131756 | 0.75 | KAT2B (0.37) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4938035 | 0.74 | ALDH1A1 (0.48) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4939291 | 0.72 | ALDH1A1 (0.47) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10132051 | 0.71 | ALDH1A1 (0.45) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13075975 | 0.70 | NPC1 (0.69) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES, L.C. | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | NPC1 585/4885ALDH1A1 1605/4885RAB9A 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.