Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18248622 | 0.99 | CYP2C19 (0.45) | CYP2C19CYP1A2ALDH1A1KCNA5KCNH2 | |
| SCHEMBL18248588 | 0.99 | CYP2C19 (0.45) | CYP2C19CYP1A2ALDH1A1KCNA5KCNH2 | |
| SCHEMBL22610224 | 0.95 | CYP2C19 (0.47) | CYP2C19CYP1A2ALDH1A1KCNA5KCNH2 | |
| SCHEMBL18248644 | 0.91 | FAAH (0.47) | CYP2C19CYP1A2MEN1KMT2ACYP3A4 | |
| SCHEMBL18248639 | 0.91 | FAAH (0.47) | CYP2C19CYP1A2MEN1KMT2ACYP3A4 | |
| SCHEMBL18248490 | 0.91 | FAAH (0.47) | CYP2C19CYP1A2MEN1KMT2ACYP3A4 | |
| SCHEMBL31295913 | 0.89 | CYP2C19 (0.49) | CYP2C19CYP1A2ALDH1A1KCNA5KCNH2 | |
| SCHEMBL27751215 | 0.89 | CYP2C19 (0.49) | CYP2C19CYP1A2ALDH1A1KCNA5KCNH2 | |
| SCHEMBL18248607 | 0.89 | KDM4E (0.47) | KDM4E | |
| SCHEMBL1065476 | 0.87 | CYP2C19 (0.44) | CYP2C19CYP1A2ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269494-A1 | Process for the Preparation of Alpha-Aryl-Alpha-Piperid-2-Yl-Acetamides and the Acid Hydrolysis Thereof | ARCHIMICA S.R.L. (IT) | 2008-10-30 | — | — | US | claimed |
| EP-1868996-A1 | A PROCESS FOR THE PREPARATION OF ALPHA-ARYL-ALPHA-PIPERID-2-YL-ACETAMIDES AND THE ACID HYDROLYSIS THEREOF | Archimica S.r.l. (IT) | 2007-12-26 | — | — | EP | claimed |
| WO-2006064052-A1 | A PROCESS FOR THE PREPARATION OF ALPHA-ARYL-ALPHA-PIPERID-2-YL-ACETAMIDES AND THE ACID HYDROLYSIS THEREOF | ARCHIMICA S.R.L. (IT) | 2006-06-22 | — | — | WO | claimed |
| US-20080269494-A1 | Process for the Preparation of Alpha-Aryl-Alpha-Piperid-2-Yl-Acetamides and the Acid Hydrolysis Thereof | ARCHIMICA S.R.L. (IT) | 2008-10-30 | — | — | US | disclosed |
| EP-1868996-A1 | A PROCESS FOR THE PREPARATION OF ALPHA-ARYL-ALPHA-PIPERID-2-YL-ACETAMIDES AND THE ACID HYDROLYSIS THEREOF | Archimica S.r.l. (IT) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006064052-A1 | A PROCESS FOR THE PREPARATION OF ALPHA-ARYL-ALPHA-PIPERID-2-YL-ACETAMIDES AND THE ACID HYDROLYSIS THEREOF | ARCHIMICA S.R.L. (IT) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269494-A1 | Process for the Preparation of Alpha-Aryl-Alpha-Piperid-2-Yl-Acetamides and the Acid Hydrolysis Thereof | ADRA2A, ARSA, CYP1A2 | CYP2C19 96/4885CYP1A2 3/4885ALDH1A1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.