Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.41 |
| ▸ | CHRNG | P07510 | 4/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.41 |
| ▸ | CHRND | Q07001 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30678696 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL500405 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ADPP7ATM | |
| Hydrochloric Acid SCHEMBL28356462 | 0.97 | LMNA (0.44) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL14511335 | 0.97 | DPP7 (0.45) | ALDH1A1MEN1KMT2ADPP7ATM | |
| Hydrochloric Acid SCHEMBL336872 | 0.97 | LMNA (0.44) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL94069 | 0.97 | DPP7 (0.45) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL2792423 | 0.97 | DPP7 (0.45) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL10939615 | 0.97 | DPP7 (0.45) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL4938808 | 0.97 | DPP7 (0.45) | ALDH1A1MEN1KMT2ADPP7ATM | |
| SCHEMBL1785534 | 0.97 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ADPP7ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-110655496-A | Method for synthesizing chiral compound | 安徽贝克联合制药有限公司 | 2020-01-07 | — | — | CN | disclosed |
| US-10406147-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2019-09-10 | — | — | US | disclosed |
| US-20190247383-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2019-08-15 | — | — | US | disclosed |
| US-10166222-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2019-01-01 | — | — | US | disclosed |
| CN-107759503-A | A kind of tetracycline derivant and application thereof | 四川科伦博泰生物医药股份有限公司 | 2018-03-06 | — | — | CN | disclosed |
| US-20180050025-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2018-02-22 | — | — | US | disclosed |
| US-9669015-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2017-06-06 | — | — | US | disclosed |
| US-20150272940-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2015-10-01 | — | — | US | disclosed |
| US-9085563-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2015-07-21 | — | — | US | disclosed |
| US-20140179737-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-8637545-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-01-28 | — | — | US | disclosed |
| EP-1867649-B1 | PIPERIDYL-2, 6-DIONE DERIVATIVES USED TO INHIBIT CELLS FROM RELEASING TUMOR NECROSIS FACTOR | TIAN JIN HEMAY BIO TECH CO LTD (CN) | 2012-12-12 | — | — | EP | disclosed |
| US-20080051432-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2008-02-28 | — | — | US | disclosed |
| EP-1867649-A1 | PIPERIDYL-2, 6-DIONE DERIVATIVES USED TO INHIBIT CELLS FROM RELEASING TUMOR NECROSIS FACTOR | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2007-12-19 | — | — | EP | disclosed |
| EP-0219852-A2 | Chartreusin derivatives, salts thereof, antitumorous compositions containing the same, and processes for producing the same | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1987-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180050025-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNFRSF9, TNFRSF1A, NGFR | ALDH1A1 2126/4885MEN1 3574/4885KMT2A 4843/4885 |
| US-10406147-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TNF, TNFRSF1A, TNFRSF9 | ALDH1A1 2567/4885MEN1 3671/4885KMT2A 4780/4885 |
| US-10166222-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TNFRSF1A, TNFRSF9, NGFR | ALDH1A1 2035/4885MEN1 3529/4885KMT2A 4841/4885 |
| US-20150272940-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | ALDH1A1 2567/4885MEN1 3671/4885KMT2A 4780/4885 |
| US-20190247383-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | ALDH1A1 2586/4885MEN1 3771/4885KMT2A 4804/4885 |
| US-20080051432-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | ALDH1A1 2567/4885MEN1 3671/4885KMT2A 4780/4885 |
| US-20140179737-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | ALDH1A1 2567/4885MEN1 3671/4885KMT2A 4780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.