Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108281 | 0.82 | ESR2 (0.44) | ESR2LMNAKMT2AMEN1ATM | |
| SCHEMBL1093738 | 0.81 | LMNA (0.47) | ESR2LMNAKMT2AMEN1ATM | |
| SCHEMBL4940862 | 0.76 | CHEK1 (0.44) | LMNAKMT2AMEN1ATMPTGS1 | |
| SCHEMBL26632940 | 0.76 | LMNA (0.45) | ESR2LMNAKMT2AMEN1ATM | |
| SCHEMBL1712290 | 0.70 | ESR2 (0.44) | ESR2LMNAKMT2AMEN1ATM | |
| SCHEMBL13436362 | 0.69 | ESR2 (0.67) | ESR2KMT2AMEN1ATMPOLB | |
| SCHEMBL4814314 | 0.67 | ESR2 (0.41) | ESR2PTGS1PTGS2RAB9ABRAF | |
| SCHEMBL9910895 | 0.66 | ESR2 (0.50) | ESR2LMNAKMT2AMEN1POLB | |
| SCHEMBL31691529 | 0.65 | LMNA (0.43) | LMNAPTGS2 | |
| SCHEMBL1094058 | 0.64 | ESR2 (0.75) | ESR2LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012051659-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-04-26 | — | — | WO | disclosed |