Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108907 | 0.84 | CDK5 (0.44) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL4940858 | 0.76 | ESR2 (0.44) | MEN1KMT2ALMNAPTGS1PTGS2 | |
| SCHEMBL2721702 | 0.72 | CHEK1 (0.54) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL9910900 | 0.70 | CHEK1 (0.59) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL9107560 | 0.68 | SLC2A1 (0.46) | NPC1RAB9A | |
| SCHEMBL29161027 | 0.68 | CHEK1 (0.56) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL2721640 | 0.67 | PTGS2 (0.46) | PTGS2 | |
| SCHEMBL15940565 | 0.67 | CHEK1 (0.51) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL4942119 | 0.66 | CHEK1 (0.46) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL15940529 | 0.64 | NPC1 (0.42) | MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012051659-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-04-26 | — | — | WO | disclosed |