Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.44 |
| ▸ | MICA | Q29983 | 1/20 | 0.44 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941013 | 1.00 | EPHX2 (0.49) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL16339449 | 0.85 | KLRK1 (0.48) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL20434045 | 0.85 | CHRM1 (0.49) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL20434130 | 0.85 | CHRM1 (0.49) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL9158572 | 0.83 | GAA (0.50) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL20434134 | 0.82 | OPRK1 (0.53) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL20434116 | 0.82 | OPRK1 (0.53) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL20434113 | 0.82 | USP9X (0.47) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL20434114 | 0.82 | USP9X (0.47) | EPHX2HPGDKMT2AKDM4EMAPT | |
| SCHEMBL14046230 | 0.81 | HDAC8 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249130-A1 | Gut microsomal triglyceride transport protein inhibitors | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20080249130-A1 | Gut microsomal triglyceride transport protein inhibitors | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249130-A1 | Gut microsomal triglyceride transport protein inhibitors | MTTP, CETP, FABP2 | EPHX2 1080/4885HPGD 717/4885KMT2A 2256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.