Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122465 | 0.84 | XIAP (0.54) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4122057 | 0.84 | XIAP (0.54) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4126331 | 0.84 | XIAP (0.54) | XIAPPSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL4114257 | 0.83 | XIAP (0.53) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4423615 | 0.81 | XIAP (0.52) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4941582 | 0.76 | XIAP (0.44) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4941581 | 0.72 | OPRM1 (0.44) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4705630 | 0.71 | XIAP (0.56) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4989954 | 0.70 | ANPEP (0.50) | XIAPANPEPCYP2D6TSHR | |
| SCHEMBL4943515 | 0.70 | XIAP (1.00) | XIAPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468365-B2 | Lactam compound | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1345955-B1 | LACTAM DIPEPTIDE AND ITS USE IN INHIBITING BETA-AMYLOID PEPTIDE RELEASE | LILLY CO ELI (US) | 2008-08-20 | — | — | EP | disclosed |
| US-20070299053-A1 | Lactam compound | ELI LILLY AND COMPANY | 2007-12-27 | — | — | US | disclosed |
| EP-1353910-B1 | LACTAM COMPOUND | LILLY CO ELI (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1341531-B1 | LACTAM COMPOUND TO INHIBIT BETA-AMYLOID PEPTIDE RELEASE OR SYNTHESIS | LILLY CO ELI (US) | 2007-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299053-A1 | Lactam compound | AAAS, ORMDL3, NAALAD2 | XIAP 3446/4885PSEN1 739/4885PSEN2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.