Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941606 | 0.81 | XIAP (0.39) | XIAPPKMAPEX1CYP2C19BLM | |
| SCHEMBL4941581 | 0.81 | OPRM1 (0.44) | XIAPOPRM1OPRK1PSEN1PSEN2 | |
| SCHEMBL4126331 | 0.78 | XIAP (0.54) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4122057 | 0.78 | XIAP (0.54) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4122465 | 0.78 | XIAP (0.54) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4941575 | 0.76 | XIAP (0.54) | XIAPCYP2C19TSHRPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL4114257 | 0.76 | XIAP (0.53) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4423615 | 0.75 | XIAP (0.52) | XIAPOPRM1OPRK1PSEN1PSEN2 | |
| SCHEMBL12536783 | 0.72 | TSHR (0.79) | PKMAPEX1CYP2C19BLMHSD17B10 | |
| SCHEMBL5984321 | 0.72 | CYP2D6 (0.51) | PKMAPEX1CYP2C19BLMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468365-B2 | Lactam compound | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1345955-B1 | LACTAM DIPEPTIDE AND ITS USE IN INHIBITING BETA-AMYLOID PEPTIDE RELEASE | LILLY CO ELI (US) | 2008-08-20 | — | — | EP | disclosed |
| US-20070299053-A1 | Lactam compound | ELI LILLY AND COMPANY | 2007-12-27 | — | — | US | disclosed |
| EP-1353910-B1 | LACTAM COMPOUND | LILLY CO ELI (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1341531-B1 | LACTAM COMPOUND TO INHIBIT BETA-AMYLOID PEPTIDE RELEASE OR SYNTHESIS | LILLY CO ELI (US) | 2007-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299053-A1 | Lactam compound | AAAS, ORMDL3, NAALAD2 | XIAP 3446/4885PKM 4517/4885APEX1 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.