Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.77 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | TP53 | P04637 | 2/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113975 | 0.92 | SMN1; SMN2 (0.74) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL158627 | 0.87 | KMT2A (1.00) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5553156 | 0.87 | MAPT (0.77) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13650924 | 0.87 | MAPT (0.77) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4942836 | 0.87 | ALDH1A1 (0.77) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| Bromide SCHEMBL3622970 | 0.86 | CYP1A1 (1.00) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22761718 | 0.85 | ALDH1A1 (0.64) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22761628 | 0.85 | MEN1 (0.64) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13650897 | 0.85 | MAPT (0.64) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| Bromide SCHEMBL22749605 | 0.85 | KMT2A (0.95) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319032-A1 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | GREIG NIGEL H | 2008-12-25 | — | — | US | disclosed |
| US-20040067991-A1 | Tetrahydrobenzothiazole analogues as neuroprotective agents | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE | 2004-04-08 | — | — | US | disclosed |
| EP-1303502-A2 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002004409-A2 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | US GOV HEALTH & HUMAN SERV (US) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067991-A1 | Tetrahydrobenzothiazole analogues as neuroprotective agents | BAX, BAD, BCL2 | ALDH1A1 1031/4885MAPT 240/4885KMT2A 3909/4885 |
| US-20080319032-A1 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS | BAX, BAD, BCL2 | ALDH1A1 1031/4885MAPT 240/4885KMT2A 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.