Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.67 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL20471926 | 1.00 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL29180544 | 1.00 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL7944810 | 1.00 | — | — | |
| Glycine SCHEMBL7122600 | 0.90 | — | — | |
| Glycine SCHEMBL28263992 | 0.90 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Lactic Acid SCHEMBL3253029 | 0.88 | TP53 (0.65) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL5921300 | 0.87 | — | — | |
| Glycine SCHEMBL28337203 | 0.87 | — | — | |
| Glycerin SCHEMBL8821885 | 0.87 | OR51E2 (0.50) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Lactic Acid SCHEMBL15441790 | 0.85 | TP53 (0.61) | GLRA1SLC6A9OR51E2GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160106077-A1 | Transgenic Animal Expressing Alzheimer's Tau Protein | AXON NEUROSCIENCE SE (SK) | 2016-04-21 | — | — | US | disclosed |
| US-9161520-B2 | Transgenic animal expressing Alzheimer's tau protein | AXON NEUROSCIENCE SE (SK) | 2015-10-20 | — | — | US | disclosed |
| US-20130179997-A1 | TRANSGENIC ANIMAL EXPRESSING ALZHEIMER'S TAU PROTEIN | AXON NEUROSCIENCE FORSCHUNGS-UND ENTWICKLUNGS GMBH (AT) | 2013-07-11 | — | — | US | disclosed |
| US-8288608-B2 | Transgenic animal expressing alzheimer's tau protein | AXON NEUROSCIENCE SE (SK) | 2012-10-16 | — | — | US | disclosed |
| EP-1521831-B1 | TRANSGENIC ANIMAL EXPRESSING TRUNCATED ALZHEIMER'S TAU PROTEIN | AXON NEUROSCIENCE (AT) | 2008-04-09 | — | — | EP | disclosed |
| US-20060112437-A1 | Transgenic animal expressing alzheimer's tau protein | AXON NEUROSCIENCE SE (CY) | 2006-05-25 | — | — | US | disclosed |
| EP-1521831-A2 | TRANSGENIC ANIMAL EXPRESSING ALZHEIMER'S TAU PROTEIN | Axon Neuroscience Forschungs- und Entwicklungs Gmbh (AT) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004007722-A2 | TRANSGENIC ANIMAL EXPRESSING ALZHEIMER’S TAU PROTEIN | AXON NEUROSCIENCE FORSCHUNGS- UND ENTWICKLUNGS GMBH (AT) | 2004-01-22 | — | — | WO | disclosed |