Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 3/20 | 0.91 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.64 |
| ▸ | SPPL2A | Q8TCT8 | 7/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15206723 | 0.95 | XIAP (1.00) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4535364 | 0.95 | XIAP (1.00) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15216926 | 0.95 | XIAP (1.00) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15206725 | 0.95 | XIAP (1.00) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4943515 | 0.95 | XIAP (1.00) | XIAPPSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL4939457 | 0.94 | XIAP (0.98) | XIAPPSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL4939467 | 0.94 | XIAP (0.98) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15216925 | 0.86 | XIAP (0.82) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7849704 | 0.83 | XIAP (0.77) | XIAPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21577575 | 0.81 | PSEN1 (0.81) | XIAPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468365-B2 | Lactam compound | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-20070299053-A1 | Lactam compound | ELI LILLY AND COMPANY | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299053-A1 | Lactam compound | AAAS, ORMDL3, NAALAD2 | XIAP 3446/4885PSEN1 739/4885PSEN2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.