Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.73 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28329021 | 1.00 | CA1 (0.73) | CA1CA4FFAR3LCKFYN | |
| Acetic Acid SCHEMBL23924735 | 0.95 | CA1 (0.80) | CA1CA4FFAR3LCKFYN | |
| Acetic Acid SCHEMBL28493690 | 0.91 | CA1 (0.73) | CA1CA4FFAR3LCKFYN | |
| Acetic Acid SCHEMBL5479034 | 0.91 | — | — | |
| Acetic Acid SCHEMBL28810668 | 0.91 | — | — | |
| Acetic Acid SCHEMBL7540275 | 0.91 | CA1 (0.73) | CA1CA4FFAR3LCKFYN | |
| Acetic Acid SCHEMBL3213377 | 0.91 | — | — | |
| Acetic Acid SCHEMBL9123559 | 0.91 | CA1 (0.73) | CA1CA4FFAR3LCKFYN | |
| Acetic Acid SCHEMBL29066511 | 0.91 | — | — | |
| Acetic Acid SCHEMBL27205411 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080057025-A1 | Method for promoting bone formation | BURKE STEVEN K | 2008-03-06 | — | — | US | disclosed |
| US-7220406-B2 | Method for promoting bone formation | GENZYME CORPORATION (US) | 2007-05-22 | — | — | US | disclosed |
| US-20040120922-A1 | Method for promoting bone formation | GENZYME CORPORATION | 2004-06-24 | — | — | US | disclosed |
| WO-2004037274-A1 | AMINE POLYMERS FOR PROMOTING BONE FORMATION | GENZYME CORPORATION (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080057025-A1 | Method for promoting bone formation | BMP2, VCL, BMP4 | CA1 3570/4885CA4 1297/4885FFAR3 4422/4885 |
| US-20040120922-A1 | Method for promoting bone formation | BMP2, VCL, BMP4 | CA1 3231/4885CA4 1310/4885FFAR3 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.