Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 3/20 | 0.46 |
| ▸ | RXRG | P48443 | 3/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23091832 | 0.90 | CES2 (0.64) | CES2LMNAPTPN1TACR1RXRA | |
| SCHEMBL23091848 | 0.82 | CES2 (0.55) | CES2LMNAPTPN1TACR1RXRA | |
| SCHEMBL29115453 | 0.82 | CES2 (0.55) | CES2LMNAPTPN1TACR1RXRA | |
| SCHEMBL1421024 | 0.82 | CES2 (0.62) | CES2LMNAP2RX1ALDH1A1 | |
| SCHEMBL30989543 | 0.81 | CES2 (0.64) | CES2LMNAPTPN1TACR1RXRA | |
| SCHEMBL1643579 | 0.80 | PTPN1 (0.73) | CES2PTPN1ALDH1A1HDAC8 | |
| SCHEMBL8911336 | 0.79 | CES2 (0.52) | CES2LMNAPTPN1TACR1RXRA | |
| SCHEMBL29115374 | 0.79 | CES2 (0.52) | CES2LMNAPTPN1TACR1RXRA | |
| SCHEMBL17291046 | 0.79 | CES2 (0.52) | CES2LMNAPTPN1TACR1P2RX1 | |
| SCHEMBL19281439 | 0.79 | CES2 (0.61) | CES2LMNAPTPN1TACR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167322-A1 | Substituted Pyrazoles as Modulators of Chemokine Receptors | MERCK SHARP & DOHME CORP. | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167322-A1 | Substituted Pyrazoles as Modulators of Chemokine Receptors | CCR1, CCR3, CCR2 | CES2 2446/4885LMNA 4743/4885PTPN1 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.