Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | CCL2 | P13500 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963719 | 0.77 | BRD4 (0.39) | BRD4CCL2NOTUMGAAKMT2A | |
| SCHEMBL3693653 | 0.74 | BRD4 (0.64) | BRD4CCL2GAAKMT2AMEN1 | |
| SCHEMBL11716478 | 0.70 | HDAC3 (0.33) | BRD4CCL2HDAC3MAOAMAOB | |
| SCHEMBL6095630 | 0.69 | TRPA1 (0.42) | NOTUMGAAKMT2ATLR9MEN1 | |
| SCHEMBL35261 | 0.69 | — | — | |
| SCHEMBL13239543 | 0.69 | CYP1A2 (0.52) | BRD4NOTUMGAAKMT2ATLR9 | |
| SCHEMBL30385312 | 0.68 | HDAC3 (0.41) | BRD4CCL2NOTUMKMT2AMEN1 | |
| SCHEMBL6017106 | 0.68 | HDAC3 (0.38) | BRD4CCL2KMT2AHDAC3CYP1A2 | |
| SCHEMBL1564351 | 0.68 | HDAC3 (0.41) | BRD4CCL2NOTUMKMT2AMEN1 | |
| SCHEMBL16140055 | 0.68 | BRD4 (0.57) | BRD4CCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180050992-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-02-22 | — | — | US | disclosed |
| US-7468365-B2 | Lactam compound | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468365-B2 | Lactam compound | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468365-B2 | Lactam compound | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1345955-B1 | LACTAM DIPEPTIDE AND ITS USE IN INHIBITING BETA-AMYLOID PEPTIDE RELEASE | LILLY CO ELI (US) | 2008-08-20 | — | — | EP | disclosed |
| US-20070299053-A1 | Lactam compound | ELI LILLY AND COMPANY | 2007-12-27 | — | — | US | disclosed |
| US-20070299053-A1 | Lactam compound | ELI LILLY AND COMPANY | 2007-12-27 | — | — | US | disclosed |
| US-20070299053-A1 | Lactam compound | ELI LILLY AND COMPANY | 2007-12-27 | — | — | US | disclosed |
| EP-1353910-B1 | LACTAM COMPOUND | LILLY CO ELI (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1341531-B1 | LACTAM COMPOUND TO INHIBIT BETA-AMYLOID PEPTIDE RELEASE OR SYNTHESIS | LILLY CO ELI (US) | 2007-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180050992-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS | MC1R, CALCRL, BDKRB2 | BRD4 1598/4885CCL2 330/4885NOTUM 379/4885 |
| US-20070299053-A1 | Lactam compound | AAAS, ORMDL3, NAALAD2 | BRD4 913/4885CCL2 3491/4885NOTUM 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.