Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 11/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946179 | 0.76 | LDLR (0.51) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL18862015 | 0.73 | ALDH1A1 (0.53) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL4946066 | 0.73 | LDLR (0.51) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL4938515 | 0.72 | LDLR (0.49) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL4945184 | 0.71 | ALDH1A1 (0.59) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL6777396 | 0.71 | LDLR (0.98) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL1577690 | 0.71 | ALDH1A1 (0.45) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL6780802 | 0.70 | LDLR (1.00) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL6783138 | 0.70 | LDLR (0.86) | LDLRNPC1GAAPKMHTT | |
| SCHEMBL6677246 | 0.70 | LDLR (0.77) | LDLRNPC1GAAPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2008-02-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045534-A1 | Derivatives of 1,3-diamino benzene as potassium channel modulators | KCNQ1, KCNQ2, KCNA1 | LDLR 4483/4885NPC1 1853/4885GAA 4250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.