Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158959 | 0.81 | POLA1 (0.43) | NT5EPNPLMNATP53HTT | |
| SCHEMBL4083226 | 0.72 | FGFR1 (0.48) | POLBPOLA1 | |
| SCHEMBL12396112 | 0.71 | POLA1 (0.43) | NT5EPNPLMNATP53HTT | |
| SCHEMBL2159905 | 0.70 | PNP (0.52) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL2159884 | 0.70 | PNP (0.52) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL12396110 | 0.70 | PNP (0.52) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL10351554 | 0.67 | NT5E (0.69) | NT5EPNPLMNATP53HTT | |
| Phosphoric Acid SCHEMBL4820778 | 0.66 | PNP (0.72) | NT5EPNPLMNATP53HTT | |
| SCHEMBL29808596 | 0.64 | NT5E (0.72) | NT5EPNPLMNATP53HTT | |
| SCHEMBL17117807 | 0.64 | NT5E (0.72) | NT5EPNPLMNATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | claimed |
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | disclosed |